- Custom medicine boxes are paperboard cartons engineered for oral syrup bottles, crimped ointment tubes, nasal sprays, eye drops and OTC remedies.
- CubitPack manufactures them starting at 1,000 boxes in 10-14 business days, with 4-5 business day rush available.
- Design help, custom dielines, dies, plates and delivery across all 50 US states are free, with guaranteed Pantone color matching.
- You review and approve a flat 2D digital proof and a 3D mockup before paying, including lot-coding windows and neck inserts.
Custom Medicine Boxes
Custom medicine boxes printed with high-contrast dosage callouts, symptom icons and Drug Facts panels for oral syrups, topical ointment tubes, nasal sprays, eye drops and first-aid kits. Orders start at 1,000 boxes, made in 10-14 business days (rush in 4-5 days), with free design help, no die or plate charges and free shipping to all 50 states. You approve a proof before payment.
What are custom medicine boxes?
Custom medicine boxes are printed paperboard folding cartons built to house over-the-counter (OTC) liquid syrups, topical cream and ointment tubes, metered nasal sprays, sterile eye drop vials, medicated patches and home first-aid kits. Because primary containers like crimped 30 g aluminum tubes or 15 ml dropper vials have tiny curved surfaces, the outer carton carries the scannable retail branding on the front and the structured 21 CFR 201.66 Drug Facts table (Active Ingredients, Purpose, Uses, Warnings and Directions) across the back and side panels. Depending on your filling line and pharmacy channel, you can specify reverse or straight tuck end flaps, auto-lock bottoms for heavy 4 fl oz and 8 fl oz syrup bottles, glued seal ends with zipper tear strips, and unvarnished lot/expiry knock-out zones. At CubitPack, custom medicine boxes start at 1,000 units in 10-14 business days, with free design help and free 50-state shipping.
Medicine boxes facts
- Minimum
- 1,000 boxes
- Turnaround
- 10-14 business days
- Rush
- 4-5 days, quoted
- Materials
- White SBS paperboard, natural kraft, recycled board, E-flute corrugated
- Printing
- CMYK, Pantone (PMS), inside carton printing for instructions, white ink
- Finishes
- Matte, gloss, soft-touch lamination, embossing (including Braille dots), spot UV, foil
- Add-ons
- Vial & dosing-cup card inserts, perforated tear strips, hang tabs, windows
- Shipping
- Free to all 50 states
Which medicine box style should I choose?
| Box style | Typical medicine format | Closure & security | Line & shelf benefit |
|---|---|---|---|
| Reverse tuck end | 15-60 g ointment tubes, eye drops, bandages | Top and bottom tuck flaps with slit locks | High sheet yield and fast cartoning |
| Straight tuck end | Nasal sprays, throat sprays, pain gels | Both flaps fold toward the back panel | Clean front face with no raw board edge |
| Auto lock bottom | 4 fl oz and 8 fl oz oral syrups | Pre-glued crash-lock floor + tuck top | Supports heavy bottles + dosing cup |
| Seal end box | Retail pharmacy OTC cartons & patches | Glued flaps with zipper tear strip | Visible tamper-evident retail opening |
| Hang tab box | First-aid ointments & hydrocortisone tubes | Tuck carton with J-hook or euro-slot header | Hangs on pharmacy pegboards or stands upright |
| Counter display (PDQ) | Single-dose vials, lozenges & travel kits | Die-cut tray with pop-up header | Ships ready for pharmacy checkout counters |
Not sure which style fits?
Request a Quote →What size medicine box do I need?
Every CubitPack medicine carton is cut to your exact inside dimensions (length × width × height in inches) with no die fee. Measure your tube crimp width, actuator height or bottle + dosing cup stack: Whether you are comparing printed medicine cartons, otc medicine packaging boxes, custom ointment and syrup boxes, drug facts folding cartons or medicine packaging with logo, we size the template to your exact container.
| Inside size (in) | Typically fits | Popular style |
|---|---|---|
| 1.25 × 1.25 × 3.25 in | 10 ml or 15 ml eye drop / ear drop bottle + folded leaflet | Reverse or straight tuck end |
| 1.625 × 1.625 × 4.25 in | 1 fl oz (30 ml) metered nasal spray or throat spray bottle | Straight tuck end with neck insert |
| 4.75 × 1.375 × 1.125 in | 15 g or 30 g crimped aluminum or laminate ointment tube | Reverse tuck end (horizontal) |
| 6.0 × 1.75 × 1.375 in | 50 g or 60 g topical pain cream or antibiotic gel tube | Reverse tuck end or hang tab |
| 2.25 × 2.25 × 5.0 in | 4 fl oz (118 ml) oral syrup bottle with over-cap dosing cup | Auto lock bottom or seal end |
| 2.625 × 2.625 × 6.0 in | 8 fl oz (236 ml) liquid medicine bottle + dosing syringe | Auto lock bottom |
Suggested inside size: 1.25 × 1.25 × 3.25 in
A starting point. Your account manager confirms the size with you before the proof.
Quote this size →Know your product's size? Work out the inside box size with our free box size calculator.
Have your inside dimensions ready? Request pricing across up to 3 quantities.
Request a Quote →How do I choose medicine boxes?
- Measure crimped tube tails or over-cap dosing cupsOn ointment tubes, the flat crimped tail is wider than the cap; on syrups, measure height with the dosing cup seated.
- Select horizontal vs vertical orientationOintment tubes usually sit horizontally for wide front branding, while nasal sprays and syrups stand vertically.
- Check how many panels your Drug Facts table needsIf your 21 CFR 201.66 Drug Facts table spills past one back panel, continue it onto the side panel or add a fifth flap.
- Choose your tamper-evident closurePick a glued seal-end carton with a zipper tear strip, or a tuck-end carton built for clear wafer seal stickers.
- Stabilize actuators and oral syringesAdd a die-cut cardboard collar or partition to hold tapered nasal sprays, droppers or oral syringes upright.
- Reserve unvarnished lot and expiry zonesLeave a coating-free knock-out window on the end flap so co-packers can inkjet or laser-etch lot and expiry codes.
What are medicine boxes made of?
Which finishes can medicine boxes have?
Which add-ons can I get?
Medicine boxes specifications
| Spec | Options |
|---|---|
| Board stock | White SBS paperboard, natural kraft, recycled board, E-flute corrugated |
| Board thickness | Card (paperboard), recycled/kraft board, corrugated or rigid board matched to product weight |
| Printing | Full color CMYK, Pantone (PMS) color matching, inside carton printing, 100% K fine text |
| Lamination | Matte, gloss or soft-touch lamination with unvarnished lot/expiry knock-out windows |
| Finishes & tactile | Embossing, debossing, spot UV, foil stamping; Braille dot embossing tooling specs |
| Closures & tamper | Reverse/straight tuck, slit locks, auto-lock bottom, glued seal end with zipper tear strip |
| Interior inserts | Die-cut cardboard neck collars, tube cradles, bottle + syringe partitions |
| Size range | Custom inside L × W × H to order; min/max folding carton dimensions |
| Minimum order | From 1,000 boxes; delivered within ±5% of ordered quantity |
| Proofs & samples | Free digital proof and 3D mockup before payment; optional printed sample credited to order |
| Turnaround | 10-14 business days standard; 4-5 business days rush |
| Shipping | Free shipping to all 50 US states; split shipping to contract packagers available |
Ready to quote your medicine boxes? Compare up to 3 quantities with a free 3D mockup.
Request a Quote →What do healthcare and wellness brands pack in custom medicine boxes?
Liquid syrups, collapsible ointment tubes and metered nasal sprays each have distinct geometry that standard square boxes cannot hold without rattling. Tell us your container dimensions and accessory count, and we engineer the carton and internal insert to fit
Medicine boxes design ideas
Example designs with made-up brands. Your packaging is made to your design.
What are the most common custom medicine box mistakes?
Most medicine carton delays happen when accessory clearance, tube crimp width or Drug Facts panel space is underestimated. When specifying medicine boxes with logo, branded medicine boxes, wholesale medicine boxes, bulk custom medicine boxes and personalized medicine boxes, avoid these common production mistakes
- Measuring only the bottle cap height on a liquid syrup while forgetting the extra 0.5 to 0.75 inch added by a snap-on plastic dosing cup.
- Sizing an ointment tube box to the round barrel diameter instead of the wider flat crimped tail at the bottom of the tube.
- Squeezing a multi-column 21 CFR 201.66 Drug Facts table below 6 pt type instead of continuing it onto the adjacent side panel.
- Applying flood UV varnish or lamination over the end flap where the co-packer's inkjet or laser lot/expiry coder needs bare board.
- Packing a tapered nasal spray or glass dropper bottle without a die-cut top neck collar, allowing the nozzle to tilt and press open the lid.
Chat with a designer now
Share your logo, a sketch or an AI image. We'll rebuild every element cleanly onto your box dieline and send a 3D mockup, free.
Made your design with AI?
Generated a concept in Google Gemini, ChatGPT, Claude or Midjourney? Send us your AI image: we rebuild every element onto your box dieline and show you a 3D mockup before you pay, free.Custom vs stock medicine boxes: which is better?
| Stock (plain) | Custom from CubitPack | |
|---|---|---|
| Tube & bottle fit | Generic sizes that let crimped tubes twist and syrup bottles tip | Built to your exact tube crimp width, cap height and dosing cup |
| Drug Facts legibility | No pre-mapped panel width for 21 CFR 201.66 tables | Panel widths and fold scores engineered around your Drug Facts layout |
| Tamper & lot coding | Plain flaps with full coating that smears inkjet lot stamps | Perforated seal-end tear strips and unvarnished lot/expiry windows |
| Minimum order | Blank unprinted cartons | From 1,000 custom printed medicine boxes |
| Lead time | Unbranded stock | 10-14 business days, or 4-5 business days rush |
Get custom medicine boxes sized to your product, with a free 3D mockup before you pay.
Request a Quote →Are medicine boxes safe and sustainable?
Tamper-evident closure options
Choose glued seal-end flaps with a perforated tear strip or tuck flaps sized for tamper-evident wafer seals.Unvarnished lot, expiry & 2D barcode zones
We mask lamination and varnish off your coding area so inkjet and laser lot/expiry stamps stay crisp.Split shipping to contract packagers
Free shipping across all 50 states, including direct flat-bundle delivery to US pharmaceutical and OTC co-packers.How do I order custom medicine boxes?
Tell us what you need
Size, quantities or AI conceptCompare volume pricing
Dedicated account managerApprove your proof
Digital proof + 3D mockupMade and shipped
Free to all 50 statesHow much do custom medicine boxes cost?
The price depends on four things, and every custom quote is free.
Carton style & closure
Tuck end cartons cost less per unit than pre-glued auto-lock bottom or fifth-panel cartonsOrder quantity & multi-SKU runs
Unit cost drops at 1,000, 2,500, 5,000 and 10,000 boxes, and Daytime/Nighttime SKUs can be quoted togetherInterior cradles
An integrated dust-flap neck cutout adds zero extra piece cost vs a separate partitionFinishes & embossing
Matte or gloss lamination is standard; foil bands or Braille embossing add a setup stepTo keep costs down across a multi-symptom line in the same 4 fl oz bottle or 30 g tube, use one universal box dieline and swap only the Pantone header and Drug Facts copy per SKU. First orders get 10% off, and we beat written US competitor quotes. Buyers ordering custom size medicine boxes or reverse medicine boxes can compare up to three quantities in one quote.
10% off your first order.
Request a Quote →What do I need to send for a quote?
- The product and how many you need
- The inside size, or what goes in it
- A style, or ask us to suggest one
- Your logo or artwork (an AI image is fine)
- Pantone codes, if you have them
- Delivery ZIP code and the date you need it
Can I see a sample first?
Sample kit
Board and finish swatches, sample boxes, labels and bags. Credited to your first order.Digital proof + 3D mockup
See it before you payPrinted sample
Of your own designHow does shipping work?
- Free shipping to all 50 states
- Worldwide with DDP prices: duties and taxes included
- Blind and split shipping
- Damaged in transit? We reprint the damaged units free
Why brands choose CubitPack
Dedicated specialist
One account manager from quote to deliveryPantone guaranteed
Clearly off? We reprintReprint or refund
If we get it wrong, you chooseBBB accredited
A US business you can checkMedicine boxes questions
What size medicine box fits a 15 g, 30 g or 60 g ointment tube?
A 15 g or 30 g tube fits a 4.75 × 1.375 × 1.125 inch horizontal carton, while a 50 g or 60 g tube fits 6.0 × 1.75 × 1.375 inches. Always measure the flat crimped tail width.
How do I size a medicine carton for a syrup bottle that has a dosing cup on top?
Place the dosing cup onto the child-resistant cap, measure total vertical height from the bottle base to the top of the cup, and add 1/8 inch (3 mm). A 4 fl oz bottle with a dosing cup uses a 2.25 × 2.25 × 5.0 inch auto-lock bottom box.
Can you make tamper-evident glued seal-end medicine boxes?
Yes. Seal-end cartons have full overlapping top and bottom flaps that your co-packer seals with hot-melt glue, paired with a perforated zipper tear strip for visible tamper evidence.
What if our OTC Drug Facts table is too long to fit on a single back panel?
On compact cartons for 10 ml eye drops or 15 g ointment tubes, a 21 CFR 201.66 Drug Facts table often continues onto the side panel. We can also add a fifth fold-out panel or print usage diagrams inside the carton.
Can you leave an unvarnished area for lot numbers, expiration dates and 2D barcodes?
Yes. Tell us which end flap or back panel your co-packer stamps, and our prepress team holds back lamination and varnish in that exact rectangle so inkjet and laser codes dry cleanly and scan reliably.
How do you keep a nasal spray bottle or glass dropper from tipping inside the box?
Nasal spray and eye drop bottles taper to a narrow actuator nozzle at the top. We design the top inner dust flaps with a die-cut circular collar that grips the nozzle neck, or add a cardboard insert cradle.
Can you add embossed Braille dots or raised tactile warnings to a medicine carton?
Yes. We can emboss raised lettering, symptom icons or Braille dot patterns onto white SBS paperboard cartons during die-cutting, keeping the embossing zone clear of fold scores.
What is the minimum order quantity for custom medicine boxes?
Our minimum order is 1,000 boxes. If you have multiple strengths, flavors or Daytime/Nighttime formulas in the same carton size, choose 2 designs or 3+ designs in the quote form to quote them together.
How long does production take for custom medicine boxes?
Standard turnaround is 10-14 business days after you approve your flat 2D proof and 3D mockup and complete payment. Rush production in 4-5 business days is available for urgent schedules.
Can you ship flat medicine cartons directly to our contract manufacturer?
Yes. Shipping is free to all 50 US states, including direct flat-bundle delivery to your contract packager or split shipments across multiple US packaging and fulfillment locations.
Still have a question? Ask a packaging specialist.
Request a Quote →Medicine boxes terms, explained
- Drug Facts panel
- The standardized 21 CFR 201.66 information table on OTC medicine cartons.
- Crimped tube tail
- The flattened sealed end of an ointment tube, which sets the minimum carton width.
- Zipper tear strip
- A double-row perforation on a glued seal-end carton that opens the top cleanly.
- Fifth-panel carton
- A folding carton with an extra hinged flap for extended Drug Facts tables.
- Over-cap dosing cup
- A graduated measuring cup that snaps over the cap of a liquid oral medicine.
- Lot/expiry knock-out
- An unvarnished flap window where inkjet or laser lot and expiry codes are applied.
More for your supplements packaging
Learn more
Get your medicine boxes price
One dedicated account manager prepares pricing across up to 3 quantities.
- Free design & AI-to-print studio + 3D mockup
- No die or plate charges · 4–5 day rush available
- Free shipping to all 50 states
- 10% off your first order
- Reprint or refund if we get it wrong
Every CubitPack fact on this page (the 1,000-box minimum, 10-14 business day turnaround, 4-5 day rush option, free design help, no die or plate charges and free 50-state shipping) comes from our published product specifications and was checked by a packaging specialist. Spot an error? Let us know and we will fix it. Tell us if something looks wrong.
Sources
What changed
- October 22, 2026: First published.
- October 22, 2026: Updated specifications, terminology, and verified source links.